Come passare il parametro all'istruzione sql 'in'?

Passalo come un array:

string[] numbers = new string[] { "123", "234" };

NpgsqlCommands cmd = new NpgsqlCommands("select * from products where number = ANY(:numbers)");
NpgsqlParameter p = new NpgsqlParameter("numbers", NpgsqlDbType.Array | NpgsqlDbType.Text);
p.value = numbers;
command.Parameters.Add(p);